phloroglucinol synthase EC#: 2.3.1.253; ChemWhat Code: 1377085
Product Name | phloroglucinol synthase |
Example Structure | |
Synonyms | PhlD, phloroglucinol synthase |
EC Number | 2.3.1.253 |
CAS Registry Number | |
Comments | The enzyme, characterized from the bacterium Pseudomonas protegens Pf-5, is a type III polyketide synthase. The mechanism involves the cyclization of an activated 3,5-dioxoheptanedioate intermediate. The enzyme exhibits broad substrate specificity, and can accept C4-C12 aliphatic acyl-CoAs and phenylacetyl-CoA as the starter molecules, forming C6-polyoxoalkylated ¦Á-pyrones by sequential condensation with malonyl-CoA. |
Cofactor | |
History | |
Reactions | 3 malonyl-CoA = phloroglucinol + 3 CO(2) + 3 CoA. |
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