phloroglucinol synthase EC#: 2.3.1.253; ChemWhat Code: 1377085

Product Name phloroglucinol synthase
Example Structure Example Structure of phloroglucinol synthase EC#: 2.3.1.253
Synonyms PhlD, phloroglucinol synthase
EC Number 2.3.1.253
CAS Registry Number
Comments The enzyme, characterized from the bacterium Pseudomonas protegens Pf-5, is a type III polyketide synthase. The mechanism involves the cyclization of an activated 3,5-dioxoheptanedioate intermediate. The enzyme exhibits broad substrate specificity, and can accept C4-C12 aliphatic acyl-CoAs and phenylacetyl-CoA as the starter molecules, forming C6-polyoxoalkylated ¦Á-pyrones by sequential condensation with malonyl-CoA.
Cofactor
History
Reactions 3 malonyl-CoA = phloroglucinol + 3 CO(2) + 3 CoA.

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