phosphatidylcholine-retinol O-acyltransferase EC#: 2.3.1.135; ChemWhat Code: 1376924
| Product Name | phosphatidylcholine-retinol O-acyltransferase |
| Example Structure |  |
| Synonyms | 11-cis-acyl-CoA:retinol O-acyltransferase, acyltransferase, lecithin-retinol, lecithin retinol acyl transferase, lecithin retinol acyltransferase, lecithin-retinol acyltransferase, lecithin/retinol acyltransferase, lecithin: retinol acyltransferase, lecithin:retinol acyl transferase, lecithin:retinol acyltransferase, LRAT, More, retinyl ester synthase, retinyl-ester synthase |
| EC Number | 2.3.1.135 |
| CAS Registry Number | 117444-03-8 |
| Comments | A key enzyme in retinoid metabolism, catalysing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form. Can also esterify 11-cis-retinol. |
| Cofactor | |
| History | |
| Reactions | Phosphatidylcholine + retinol–[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester–[cellular-retinol-binding- protein]. |
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