phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase EC#: 3.1.3.67; ChemWhat Code: 1379497

Product Name phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
Example Structure Example Structure of phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase EC#: 3.1.3.67
Synonyms 1-phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase, MMAC1/TEP1, phosphatase and tensin homolog, phosphatase and tensin homologue, phosphatase and tensin homologue deleted on chromosome 10, phosphatidylinositol 3,4,5-trisphosphate-specific phosphatase, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, PI 3-phosphatase, PTEN, PTEN phosphatase, PTEN/MMAC, PTEN/MMAC1, SidF, TPIP, tumor suppressor PREN, voltage-sensing phosphatase, Voltage-sensing phosphoinositide phosphatase, VSP
EC Number 3.1.3.67
CAS Registry Number
Comments Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4?to Ins(1,4,5)P3?.
Cofactor Mg2+
History
Reactions Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.

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