phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase EC#: 3.1.3.67; ChemWhat Code: 1379497
| Product Name | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
| Example Structure |  |
| Synonyms | 1-phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase, MMAC1/TEP1, phosphatase and tensin homolog, phosphatase and tensin homologue, phosphatase and tensin homologue deleted on chromosome 10, phosphatidylinositol 3,4,5-trisphosphate-specific phosphatase, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, PI 3-phosphatase, PTEN, PTEN phosphatase, PTEN/MMAC, PTEN/MMAC1, SidF, TPIP, tumor suppressor PREN, voltage-sensing phosphatase, Voltage-sensing phosphoinositide phosphatase, VSP |
| EC Number | 3.1.3.67 |
| CAS Registry Number | |
| Comments | Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4?to Ins(1,4,5)P3?. |
| Cofactor | Mg2+ |
| History | |
| Reactions | Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate. |
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