phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase EC#: 3.1.3.86; ChemWhat Code: 1379529

Product Name phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
Example Structure Example Structure of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase EC#: 3.1.3.86
Synonyms 150-kD IP5Pase, 5′-inositol phosphatase, 75 kDa 5-phosphatase, 75 kDa inositol polyphosphate 5-phosphatase, membrane-associated, inositol polyphosphate 5-phosphatase, INPP5D, INPP5K, INPPL1, p150SHIP, phosphatidylinositol (3,4,5)-trisphosphate 5-phosphatase, phosphatidylinositol 3,4,5 trisphosphate 5-phosphatase, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, phosphatidylinositol 5-phosphatase, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, Phosphoinositide 5-phosphatase, PI 5-phosphatase, PI(3,4,5)P3 5-phosphatase, PIP3 5-phosphatase, PIP5Pase, PtdIns(3,4,5)-P3 phosphatase, PtdIns(3,4,5)P3 5-phosphatase, PtdIns(3,4,5)P3 phosphatase, SH2 domain containing 5-phosphatase, SH2 domain containing inositol 5-phosphatase, SH2 domain containing inositol 5-phosphatase 2, SH2 domain-containing inositol 5-phosphatase, SH2 domain-containing inositol 5-phosphatase 2, SH2 domain-containing inositol polyphosphate 5-phosphatase 2, SH2-containing inositol phosphatase, SH2-containing-inositol-5-phosphatase 2, SH2-domain-containing 5 inositol phosphatase, SH2-domain-containing 5-inositol phosphatase, Shc-associated p145 protein, SHIP, SHIP-1, SHIP-2, SHIP1, SHIP2, SKIP, Src homology 2 containing inositol 5-phosphatase 2, Src homology 2 domain containing inositol 5-phosphatase, src homology 2 domain-containing inositol 5-phosphatase 2, Src homology 2 domain-containing inositol polyphosphate 5-phosphatase 2, Src homology 2-containing inositol phosphatase 1, Synaptojanin
EC Number 3.1.3.86
CAS Registry Number
Comments This enzyme hydrolyses phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward PtdIns(1,3,4,5)P4?[5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
Cofactor
History
Reactions 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.

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