phosphoglycerol geranylgeranyltransferase EC#: 2.5.1.41; ChemWhat Code: 1377938
| Product Name | phosphoglycerol geranylgeranyltransferase |
| Example Structure |  |
| Synonyms | ((S)-GGGP) synthase, (S)-3-O-geranylgeranylglyceryl phosphate synthase, (S)-3-O-geranylgeranylglycerylphosphate, geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase, geranylgeranyl-transferase, geranylgeranylglycerol-phosphate geranylgeranyltransferase, geranylgeranylglyceryl phosphate synthase, geranylgeranyltransferase II, geranylgeranyltransferase, geranylgeranyloxyglycerol phosphate, GGGP synthase, GGGPS, glycerol phosphate feranylgeranyltransferase, prenyltransferase |
| EC Number | 2.5.1.41 |
| CAS Registry Number | 124650-69-7 |
| Comments | This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria [2]. Requires Mg2+ for maximal activity [2]. It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC 2.7.7.67 (CDP-archaeol synthase), which lead to the formation of CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [5]. |
| Cofactor | Mg2+ |
| History | |
| Reactions | Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate. |
Buy Reagent | |
| No reagent supplier? | Send quick inquiry to ChemWhat |
| Want to be listed here as a reagent supplier? (Paid service) | Click here to contact ChemWhat |
Approved Manufacturers | |
| Want to be listed as an approved manufacturer (Requires approvement)? | Please download and fill out this form and send back to approved-manufacturers@chemwhat.com |
Contact Us for Other Help | |
| Contact us for other information or services | Click here to contact ChemWhat |