phosphohistidine phosphatase EC#: 3.9.1.3; ChemWhat Code: 1381831
| Product Name | phosphohistidine phosphatase |
| Example Structure |  |
| Synonyms | 14 kDa phosphohistidine phosphatase, 14-kDa phosphohistidine phosphatase, 16 kDa protein histidine phosphatase, histidine protein phosphatase, phospho-histidine phosphatase, phosphohistidine phosphatase, phosphohistidine phosphatase 1, phosphohistidine phosphatase I, phosphopolyhistidine phosphatase, PHP, PHP14, PHPT-1, PHPT1, PHPTI, PP1, PP2A, protein histidine phosphatase, protein histidine phosphatase 1, protein-histidine phosphatase, SixA |
| EC Number | 3.9.1.3 |
| CAS Registry Number | |
| Comments | This eukaryotic enzyme dephosphorylates phosphorylated histidine residues within proteins and peptides. The enzyme acts on phosphate groups attached to both the?pros- and?tele-nitrogen atoms, but the?pros- position is somewhat preferred (by a factor of two at the most) [4]. The substrate specificity depends on the amino acid sequence or structural context of the phosphohistidine in a phosphoprotein. The enzyme is also active on free phosphoramidate [1,4] and peptide-bound phospholysine [5]. |
| Cofactor | |
| History | |
| Reactions | A [protein]-N-phospho-L-histidine + H(2)O = a [protein]-L-histidine + phosphate. |
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