phosphonopyruvate hydrolase EC#: 3.11.1.3; ChemWhat Code: 1381840

Product Name phosphonopyruvate hydrolase
Example Structure Example Structure of phosphonopyruvate hydrolase EC#: 3.11.1.3
Synonyms PalA, PPH
EC Number 3.11.1.3
CAS Registry Number
Comments Highly specific for phosphonopyruvate as substrate [2]. The reaction is not inhibited by phosphate but is inhibited by the phosphonates phosphonoformic acid, hydroxymethylphosphonic acid and 3-phosphonopropanoic acid [2]. The enzyme is activated by the divalent cations Co2+, Mg2+?and Mn2+. This enzyme is a member of the phosphoenolpyruvate mutase/isocitrate lyase superfamily [3].
Cofactor Mg2+?or?cobalt cation?or?Mn2+
History
Reactions 3-phosphonopyruvate + H(2)O = pyruvate + phosphate.

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