pimeloyl-[acyl-carrier protein] synthase EC#: 1.14.14.46; ChemWhat Code: 1375554

Product Name pimeloyl-[acyl-carrier protein] synthase
Example Structure Example Structure of pimeloyl-[acyl-carrier protein] synthase EC#: 1.14.14.46
Synonyms CYP107H1, cytochrome P450BioI, fatty acid hydroxylase, P450 BioI, P450BioI
EC Number 1.14.14.46
CAS Registry Number
Comments A cytochrome P450 (heme-thiolate) protein. The enzyme catalyses an oxidative C-C bond cleavage of long-chain acyl-[acyl-carrier protein]s of various lengths to generate pimeloyl-[acyl-carrier protein], an intermediate in the biosynthesis of biotin. The preferred substrate of the enzyme from the bacterium Bacillus subtilis is palmitoyl-[acyl-carrier protein] which then gives heptanal as the alkanal. The mechanism is similar to EC 1.14.15.6, cholesterol monooxygenase (side-chain-cleaving), followed by a hydroxylation step, which may occur spontaneously [2].
Cofactor heme-thiolate
History
Reactions A long-chain acyl-[acyl-carrier protein] + 2 reduced flavodoxin + 3 O(2) = pimeloyl-[acyl-carrier protein] + an n-alkanal + 2 oxidized flavodoxin + 3 H(2)O.

Buy Reagent

No reagent supplier? Send quick inquiry to ChemWhat
Want to be listed here as a reagent supplier? (Paid service) Click here to contact ChemWhat

Approved Manufacturers

Want to be listed as an approved manufacturer (Requires approvement)? Please download and fill out this form and send back to approved-manufacturers@chemwhat.com

Contact Us for Other Help

Contact us for other information or services Click here to contact ChemWhat