pitrilysin EC#: 3.4.24.55; ChemWhat Code: 1381047
| Product Name | pitrilysin |
| Example Structure |  |
| Synonyms | EC 3.4.99.44, Escherichia coli protease III, Pitrilysin, ppBH4, Protease Pi, Proteinase Pi, Proteinase, Escherichia coli metallo-, Pi, PTR |
| EC Number | 3.4.24.55 |
| CAS Registry Number | 81611-78-1 |
| Comments | From the periplasmic space of?Escherichia coli. Inhibited by EDTA and 1,10-phenanthroline; not thiol-dependent. Formerly EC?3.4.99.44. Type example of peptidase family?M16. |
| Cofactor | Zn2+ |
| History | |
| Reactions | Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon. |
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