| Product Name |
precorrin-3B C17-methyltransferase |
| Example Structure |
 |
| Synonyms |
Gene cobJ enzyme, Precorrin-3 C-17 methyltransferase, Precorrin-3 methylase, Precorrin-3 methyltransferase, Precorrin-3B methyltransferase, Precorrin-4 synthase, SAM-dependent C-17 methyl transferase, Synthase, precorrin-4 |
| EC Number |
2.1.1.131 |
| CAS Registry Number |
152787-64-9 |
| Comments |
In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively. |
| Cofactor |
|
| History |
|
| Reactions |
S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4. |
