preQ1 synthase EC#: 1.7.1.13; ChemWhat Code: 1374611

Product Name preQ1 synthase
Example Structure Example Structure of preQ1 synthase EC#: 1.7.1.13
Synonyms 7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase, 7-cyano-7-deazaguanine reductase, NADPH-dependent 7-cyano-7-deazaguanine reductase, nitrile reductase, NRed, preQ0 reductase, preQ0oxidoreductase, QueF, queuine synthase, YkvM
EC Number 1.7.1.13
CAS Registry Number 1256460-80-6
Comments The reaction occurs in the reverse direction. This enzyme catalyses one of the early steps in the synthesis of queosine (Q-tRNA), and is followed by the action of EC 2.4.2.29, tRNA-guanosine34 transglycosylase. Queosine is found in the wobble position of tRNAGUN in Eukarya and Bacteria [2] and is thought to be involved in translational modulation. The enzyme is not a GTP cyclohydrolase, as was thought previously based on sequence-homology studies.
Cofactor
History
Reactions 7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-carbaguanine + 2 Nadph.

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