procollagen-proline 3-dioxygenase EC#: 1.14.11.7; ChemWhat Code: 1375079
| Product Name | procollagen-proline 3-dioxygenase |
| Example Structure |  |
| Synonyms | LEPRE1, Leprel1, Leprel2, More, oxygenase, protocollagen proline 3-di-, P3H1, P3H2, P3H3, PHD3, proline,2-oxoglutarate 3-dioxygenase, prolyl 3-hydroxylase, prolyl 3-hydroxylase 1, prolyl 3-hydroxylase-2, prolyl hydroxylase, prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating, protocollagen proline 3-hydroxylase |
| EC Number | 1.14.11.7 |
| CAS Registry Number | 63551-75-7 |
| Comments | Requires Fe2+ and ascorbate. The enzyme forms a complex with protein disulfide isomerase, and is located in the endoplasmic reticulum. It modifies proline residues within the procollagen peptide of certain collagen types. The modification is essential for proper collagen triple helix formation. |
| Cofactor | Fe2+;L-ascorbate |
| History | |
| Reactions | L-proline-[procollagen] + 2-oxoglutarate + O(2) = trans-3-hydroxy-L- proline-[procollagen] + succinate + CO(2). |
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