proline 3-hydroxylase EC#: 1.14.11.28; ChemWhat Code: 1375110
| Product Name | proline 3-hydroxylase |
| Example Structure |  |
| Synonyms | C-P3H, C-P4H, collagen prolyl hydroxylases 3, collagen prolyl hydroxylases 4, L-proline-3-hydroxylase, Leprel1, Leprel2, P-3-H, P3H, P3H1, P3H2, P3H3, proline 3-hydroxylase, proline 3-hydroxylase type I, proline 3-hydroxylase type II, prolyl 3-hydrolase, prolyl 3-hydroxylase 2 |
| EC Number | 1.14.11.28 |
| CAS Registry Number | |
| Comments | Requires iron(II) for activity. Unlike the proline hydroxylases involved in collagen biosynthesis [EC 1.14.11.2 (procollagen-proline dioxygenase) and EC 1.14.11.7 (procollagen-proline 3-dioxygenase)], this enzyme does not require ascorbate for activity although it does increase the activity of the enzyme [2]. The enzyme is specific for L-proline as D-proline, trans-4-hydroxy-L-proline, cis-4-hydroxy-L-proline and 3,4-dehydro-DL-proline are not substrates [2]. |
| Cofactor | Fe2+ |
| History | |
| Reactions | L-proline + 2-oxoglutarate + O(2) = cis-3-hydroxy-L-proline + succinate + CO(2). |
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