proteasome endopeptidase complex EC#: 3.4.25.1; ChemWhat Code: 1381106
| Product Name | proteasome endopeptidase complex |
| Example Structure |  |
| Synonyms | 20 S proteasome, 206 proteasome, 20S CP, 20S protease core, 20S proteasome, 26 S proteasome, 26S protease, 26S proteasome, 26S proteasome complex, 27 kDa prosomal protein, 30 kDa prosomal protein, beta1-PF1404, c20S, Component Y8, constitutive proteasome 20S, EC 3.4.99.46, GPRO-28, HsBPROS26, HSN3, i20S, immunoproteasome 20S, ingensin, KIPase, large multicatalytic protease, macropain, multi-subunit protease complex, multicatalytic endopeptidase complex, Multicatalytic endopeptidase complex C7, multicatalytic protease, multicatalytic proteinase, p27K, PROS-27, PROS-30, PROS-Dm25, PROS-Dm28.1, PROS-Dm29, PROS-Dm35, Pros26.4, prosome, proteasome, proteasome 19S, proteasome 20S, Proteasome component C13, Proteasome component C2, Proteasome component C3, Proteasome component C5, Proteasome component C8, Proteasome component C9, Proteasome component DD4, Proteasome component DD5, Proteasome component pts1, PSMA5, RING12 protein, RN3, SCL1 suppressor protein, T20S, TAS-F22/FAFP98, TAS-G64, TCPR29, tricorn protease, tricorn proteinase, XC3 |
| EC Number | 3.4.25.1 |
| CAS Registry Number | 140879-24-9 |
| Comments | A 20-S protein composed of 28 subunits arranged in four rings of seven. The outer rings are composed of?a?subunits, but the?b?subunits forming the inner rings are responsible for peptidase activity. In eukaryotic organisms there are up to seven different types of?b?subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities. The molecule is barrel-shaped, and the active sites are on the inner surfaces. Terminal apertures restrict access of substrates to the active sites. There is evidence that catalytic subunits are replaced by others under some conditions so as to alter the specificity of proteolysis, perhaps optimizing it for the formation of antigenic peptides. A complex of the 20-S proteasome endopeptidase complex with a 19-S regulatory unit is the 26-S proteasome that degrades ubiquitin-protein conjugates. Type example of peptidase family?T1. Formerly EC?3.4.24.5, EC?3.4.22.21?and EC?3.4.99.46. |
| Cofactor | |
| History | |
| Reactions | Cleavage of peptide bonds with very broad specificity. |
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