protein deglycase EC#: 3.5.1.124; ChemWhat Code: 1381340
| Product Name | protein deglycase |
| Example Structure |  |
| Synonyms | deglycase, DJ-1, DJ-1 protein, glutathione-independent glyoxalase, glutathione-independent glyoxalases, also called glyoxalases, glyoxalase, glyoxylase III, hchA, Hsp31, III, Maillard deglycase, More, PARK7, Parkinsonism-associated protein, Parkinsonism-associated protein DJ-1, PfpI, yajL, yhbO |
| EC Number | 3.5.1.124 |
| CAS Registry Number | |
| Comments | The enzyme, previously thought to be a glyoxalase, acts on glycated?L-arginine,?L-lysine, and?L-cysteine residues within proteins that have been attacked and modified by glyoxal or 2-oxopropanal. The attack forms hemithioacetal in the case of cysteines and aminocarbinols in the case of arginines and lysines. The enzyme repairs the amino acids, releasing glycolate or lactate (70-80% (S)-lactate and 20-30% (R)-lactate), depending on whether the attacking agent was glyoxal or 2-oxopropanal, respectively. |
| Cofactor | |
| History | |
| Reactions | (1) An N(omega)-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine + H(2)O = a [protein]-L-arginine + (R)-lactate. (2) An N(6)-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H(2)O = a [protein]-L-lysine + (R)-lactate. (3) An S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine + H(2)O = a [protein]-L-cysteine + (R)-lactate. |
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