protein-fructosamine 3-kinase EC#: 2.7.1.171; ChemWhat Code: 1378560

Product Name protein-fructosamine 3-kinase
Example Structure Example Structure of protein-fructosamine 3-kinase EC#: 2.7.1.171
Synonyms FL3P, FN3K, fructosamine 3 kinase, fructosamine 3-kinase, fructosamine-3-kinase, fructose-3-kinase, ketosamine 3-kinase 1
EC Number 2.7.1.171
CAS Registry Number
Comments Nonenzymatic glycation is an important factor in the pathogenesis of diabetic complications. Key early intermediates in this process are fructosamines, such as [protein]-N6-D-fructosyl-L-lysine. Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from nonenzymatically glycated proteins. The phosphorylation destablilizes the [protein]-N6-D-fructosyl-L-lysine adduct and leads to its spontaneous decomposition. cf. EC?2.7.1.172, protein-ribulosamine 3-kinase.
Cofactor
History
Reactions Atp + [protein]-N(6)-D-fructosyl-L-lysine = adp + [protein]-N(6)-(3-O- phospho-D-fructosyl)-L-lysine.

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