| Synonyms |
C8orf32, Cg8253, CT1, FLJ10204, glutamine-specific N-terminal amidase, hNtaq1, human N-terminal glutamine amidohydrolase isoform 1, N-terminal amidase, Nt-amidase, NTA1, Ntaq, NTAQ1, NtQ-amidase, Wdyhv1, yNta1 |
| Comments |
This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Gln. Following the acetylation and removal of the initiator methionine, the exposed N-terminal glutamine is deaminated, resulting in its conversion to?L-glutamate. The latter serves as a substrate for EC?2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. |
