protein N-terminal glutamine amidohydrolase EC#: 3.5.1.122; ChemWhat Code: 1381337
| Product Name | protein N-terminal glutamine amidohydrolase |
| Example Structure |  |
| Synonyms | C8orf32, Cg8253, CT1, FLJ10204, glutamine-specific N-terminal amidase, hNtaq1, human N-terminal glutamine amidohydrolase isoform 1, N-terminal amidase, Nt-amidase, NTA1, Ntaq, NTAQ1, NtQ-amidase, Wdyhv1, yNta1 |
| EC Number | 3.5.1.122 |
| CAS Registry Number | |
| Comments | This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Gln. Following the acetylation and removal of the initiator methionine, the exposed N-terminal glutamine is deaminated, resulting in its conversion to?L-glutamate. The latter serves as a substrate for EC?2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. |
| Cofactor | |
| History | |
| Reactions | N-terminal L-glutaminyl-[protein] + H(2)O = N-terminal L-glutamyl- [protein] + NH(3). |
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