protein N-terminal monomethyltransferase EC#: 2.1.1.299; ChemWhat Code: 1376577
Product Name | protein N-terminal monomethyltransferase |
Example Structure | |
Synonyms | METTL11B, N-terminal monomethylase, NRMT2 |
EC Number | 2.1.1.299 |
CAS Registry Number | |
Comments | This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal. |
Cofactor | |
History | |
Reactions | S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L- homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein]. |
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