protoasukamycin 4-monooxygenase EC#: 1.14.13.215; ChemWhat Code: 1375457
| Product Name | protoasukamycin 4-monooxygenase |
| Example Structure |  |
| Synonyms | asuE1, flavin-dependent protoasukamycin hydroxylase, protoasukamycin 4-hydroxylase |
| EC Number | 1.14.13.215 |
| CAS Registry Number | |
| Comments | The enzyme, characterized from the bacterium Streptomyces nodosus subsp. asukaensis, is involved in the biosynthesis of the antibiotic asukamycin. Requires a flavin cofactor, with no preference among FMN, FAD or riboflavin. When flavin concentration is low, activity is enhanced by the presence of the NADH-dependent flavin-reductase AsuE2. |
| Cofactor | flavin |
| History | |
| Reactions | Protoasukamycin + Nadh + O(2) = 4-hydroxyprotoasukamycin + NAD(+) + H(2)O. |
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