pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase EC#: 4.4.1.37; ChemWhat Code: 1382955
Product Name | pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase |
Example Structure | |
Synonyms | LarE, P2CMN sulfurtransferase, P2TMN synthase, pyridinium-3,5-biscarboxylic acid mononucleotide sulfurtransferase |
EC Number | 4.4.1.37 |
CAS Registry Number | |
Comments | This enzyme, found in?Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. The process starts when one enzyme molecule adenylates pyridinium-3,5-dicarboxylate mononucleotide (P2CMN) and covalently binds the adenylated product to an intrinsic cysteine residue. Next, the enzyme cleaves the carbon-sulfur bond, liberating pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide (PCTMN) and leaving a 2-aminoprop-2-enoate (dehydroalanine) residue attached to the protein. Since the cysteine residue is not regenerated?in vivo, the enzyme is inactivated during the process. A second enzyme molecule then repeats the process with PCTMN, adenylating it and covalently binding it to the same cysteine residue, followed by liberation of pyridinium-3,5-bisthiocarboxylate mononucleotide (P2TMN) and the inactivation of the second enzyme molecule. |
Cofactor | |
History | |
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