In?Escherichia coli, the coenzyme pyridoxal 5′-phosphate is synthesized de novo by a pathway that involves EC?1.2.1.72?(erythrose-4-phosphate dehydrogenase), EC?1.1.1.290?(4-phosphoerythronate dehydrogenase), EC?2.6.1.52?(phosphoserine transaminase), EC?1.1.1.262?(4-hydroxythreonine-4-phosphate dehydrogenase), EC?2.6.99.2?(pyridoxine 5′-phosphate synthase) and EC?1.4.3.5?(with pyridoxine 5′-phosphate as substrate). 1-Deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate [3].
