pyrimidine-nucleoside phosphorylase EC#: 2.4.2.2; ChemWhat Code: 1377715

Product Name pyrimidine-nucleoside phosphorylase
Example Structure Example Structure of pyrimidine-nucleoside phosphorylase EC#: 2.4.2.2
Synonyms phosphorylase, pyrimidine nucleoside, Py-NPase, PYNP, pynpase, pyrimidine nucleoside phosphorylase, pyrimidine ribonucleoside phosphorylase, TTHA1771
EC Number 2.4.2.2
CAS Registry Number 9055-35-0
Comments Unlike EC 2.4.2.3, uridine phosphorylase, EC 2.4.2.4, and thymidine phosphorylase, this enzyme can accept both the ribonucleoside uridine and the 2′-deoxyribonucleosides 2′-deoxyuridine and thymidine [3]. The reaction is reversible, and the enzyme does not distinguish between ¦Á-D-ribose 1-phosphate and 2-deoxy-¦Á-D-ribose 1-phosphate in the synthetic direction.
Cofactor
History
Reactions (1) Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. (2) Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. (3) 2′-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate.

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