| Product Name |
pyroglutamyl-peptidase II |
| Example Structure |
 |
| Synonyms |
(fMet)-releasing enzyme, Aminopeptidase, formylmethionine, Formylmethionine aminopeptidase |
| EC Number |
3.4.19.6 |
| CAS Registry Number |
60063-88-9 |
| Comments |
Highly specific for thyrotropin releasing hormone (pyroglutamyl-histidyl-prolylamide). Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone releasing hormone. Found in serum and brain. Inhibited by metal chelators. In peptidase family?M1?(membrane alanyl aminopeptidase family). |
| Cofactor |
Zn2+ |
| History |
|
| Reactions |
Release of the N-terminal pyroglutamyl group from pGlu-|-His-Xaa tripeptides and pGlu-|-His-Xaa-Gly tetrapeptides. |
