| Product Name |
pyrrolysine-tRNAPyl ligase |
| Example Structure |
 |
| Synonyms |
class II aminoacyl-tRNA synthetase, DhaPylSc, LysZ-RS, More, PylRS, PylS, PylSc, PylSn, pyrrolysyl-tRNA synthetase |
| EC Number |
6.1.1.26 |
| CAS Registry Number |
|
| Comments |
In organisms such as?Methanosarcina barkeri?that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNAPyl, with a CUA anticodon, can be charged directly with pyrrolysine by this class II aminoacyl¡ªtRNA ligase. The enzyme is specific for pyrrolysine as substrate as it cannot be replaced by lysine or any of the other natural amino acids [1]. |
| Cofactor |
|
| History |
|
| Reactions |
Atp + L-pyrrolysine + tRNA(Pyl) = amp + diphosphate + L-pyrrolysyl- tRNA(Pyl). |
