quorum-quenching N-acyl-homoserine lactonase EC#: 3.1.1.81; ChemWhat Code: 1379294
| Product Name | quorum-quenching N-acyl-homoserine lactonase |
| Example Structure |  |
| Synonyms | AaL, acyl homoserine degrading enzyme, adeH, AHL, AHL lactonase, AHL lactonase AiiAAI96, ahl-1, AHL-acylase, AHL-degrading enzyme, AHL-inactivating enzyme, AHL-lactonase, AHLase, AhlD, AhlK, AhlS, AidC, AidH, AidP, Aii20J, Aii810, AiiA, AiiA lactonase, AiiA-like protein, AiiATSAWB, AiiB, AiiC, aiiE, AiiK, AiiM, AiiT, AmiE, AttM, auto-inducer inhibitor from Cyanobacteria, autoinducer inactivator A, BlcC, BpiB05, cold-adapted N-acylhomoserine lactonase, delactonase, GKL, h-PON1, HqiA, human paraoxonase 1, lactonase-like enzyme, lactonase/phosphotriesterase, MomL, More, N-acyl homoserine lactonase, N-acyl homoserine lactone hydrolase, N-acyl-homoserine lactonase, N-acyl-homoserine lactone lactonase, N-acyl-homoserine-lactonase, N-acyl-L-homoserine lactone hydrolase, N-acyl-L-homoserine lactone lactonase, N-acylhomoserine lactonase, N-AHSL lactonase, N007_09425, NAHL-lactonase, OPH, organophosphorus hydrolase, paraoxonase, paraoxonase 1, phosphotriesterase-like lactonase, PHP, PLL, POX, QlcA, QsdA, qsdS, quorum quenching AHL-lactonase, quorum quenching lactonase, quorum-quenching enzyme, quorum-quenching lactonase, quorum-quenching N-acyl homoserine lactonase, quorum-quenching N-acyl homoserine lactone hydrolase, quorum-quenching N-acyl homoserine lactone lactonase, quorum-sensing enzyme, quorum-sensing lactonase, RmmL, SSO2522, SsoPox, VmoLac, VMUT_2255 |
| EC Number | 3.1.1.81 |
| CAS Registry Number | 389867-43-0 |
| Comments | Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria [5].?N-(3-Oxohexanoyl)-L-homoserine lactone,?N-(3-oxododecanoyl)-L-homoserine lactone,?N-butanoyl-L-homoserine lactone and?N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates [5]. |
| Cofactor | |
| History | |
| Reactions | An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine. |
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