(R)-2-hydroxyisocaproyl-CoA dehydratase EC#: 4.2.1.157; ChemWhat Code: 1382473

Product Name (R)-2-hydroxyisocaproyl-CoA dehydratase
Example Structure Example Structure of (R)-2-hydroxyisocaproyl-CoA dehydratase EC#: 4.2.1.157
Synonyms 2-hydroxyisocaproyl-CoA dehydratase, HadBC, HadBC dehydratase
EC Number 4.2.1.157
CAS Registry Number
Comments The enzyme, isolated from the bacterium?Peptoclostridium difficile, is involved in the reductive branch of?L-leucine fermentation. It catalyses an ¦Á/¦Â-dehydration, which depends on the reductive formation of ketyl radicals on the substrate generated by injection of a single electron from the ATP-dependent activator protein HadI.
Cofactor
History
Reactions (R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H(2)O.

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