(R)-citramalate synthase EC#: 2.3.1.182; ChemWhat Code: 1376987
| Product Name | (R)-citramalate synthase |
| Example Structure |  |
| Synonyms | CimA, cimA protein, CimA3.7, citramalate lyase, citramalate synthase, CMS, DET0825, LA2350, LiCMS, LiCMSC |
| EC Number | 2.3.1.182 |
| CAS Registry Number | |
| Comments | One of the enzymes involved in a novel pyruvate pathway for isoleucine biosynthesis that is found in some, mainly archaeal, bacteria [1,2]. The enzyme can be inhibited by isoleucine, the end-product of the pathway, but not by leucine [2]. The enzyme is highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate [1,2]. |
| Cofactor | |
| History | |
| Reactions | Acetyl-CoA + pyruvate + H(2)O = CoA + (2R)-2-hydroxy-2- methylbutanedioate. |
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