Recombinant Human Growth Differentiation Factor 5/Bone Morphogenetic Protein-14 (rHuGDF-5/BMP-14, P43026, 8200) CAS#: 108-14-1816; ChemWhat Code: 1404862

Official Full Name Recombinant Human Growth Differentiation Factor 5/Bone Morphogenetic Protein-14 (rHuGDF-5/BMP-14)
Squence Squence of Recombinant Human Growth Differentiation Factor 5/Bone Morphogenetic Protein-14
Amino Acid Sequence APLATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR
Synonyms
Accession Number P43026
GeneID 8200
Summary Growth/differentiation factors (GDF-1 to GDF-15) are members of the BMP family of TGF-beta superfamily proteins. They are produced as inactive preproproteins which are then cleaved and assembled into active secreted homodimers. GDF dimers are disulfide-linked with the exception of GDF-3 and -9. GDF proteins are important during embryonic development, particularly in the skeletal, nervous, and muscular systems.
Source
Molecular Weight Approximately 27.1 kDa, a disulfide-linked homodimeric protein containing two 120 amino acids.
Biological Activity Fully biologically active when compared to standard. The ED50 as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 1.0 ug/ml, corresponding to a specific activity of > 1000 IU/mg.
Appearance Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation Lyophilized from a 0.2 um filtered concentrated solution in 30 % Acetonitrile and 0.1 % TFA.
Endotoxin Less than 0.1 EU/ug of rHuGDF-5/BMP-14 as determined by LAL method.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 4 mM HCl to a concentration of 0.1-1.5 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
References
SDS-PAGE SDS-PAGE of Recombinant Human Growth Differentiation Factor 5/Bone Morphogenetic Protein-14
Safety Data Sheet (SDS) Download Click to download
Technical Data Sheet (TDS) Download Click to download

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