renalase EC#: 1.6.3.5; ChemWhat Code: 1374523

Product Name renalase
Example Structure Example Structure of renalase EC#: 1.6.3.5
Synonyms alphaNAD(P)H oxidase/anomerase, REN, Ren-1, Ren-2, renalase-1, renalase-2
EC Number 1.6.3.5
CAS Registry Number
Comments Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of ¦Â-NAD(P)H back to ¦Â-NAD(P)+. These isomeric forms, generated by nonspecific reduction of ¦Â-NAD(P)+ or by tautomerization of ¦Â-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
Cofactor FAD
History
Reactions (1) 1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2). (2) 1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).

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