Cg2114, LexA, LexA protein, LexA repressor, LexA transcriptional repressor, SOS regulatory protein dinR
EC Number
3.4.21.88
CAS Registry Number
84721-00-6
Comments
RecA protein and single-stranded DNA are required for activity, which is attributed to a Ser/Lys dyad [2]. The LexA protein represses the SOS regulon, which regulates the genes involved in DNA repair. In the presence of single-stranded DNA, the RecA protein interacts with repressor LexA, causing it to undergo an autocatalytic cleavage which disrupts the DNA-binding part of the repressor, and inactivates it. The consequent derepression of the SOS regulon leads to DNA repair. This peptidase activity of LexA was previously attributed to the RecA protein (formerly EC?3.4.99.37). Type example of peptidase family?S24.
