ribonuclease D EC#: 3.1.13.5; ChemWhat Code: 1379720
| Product Name | ribonuclease D |
| Example Structure |  |
| Synonyms | RNase D |
| EC Number | 3.1.13.5 |
| CAS Registry Number | |
| Comments | Requires divalent cations for activity (Mg2+, Mn2+?or Co2+). Alteration of the 3′-terminal base has no effect on the rate of hydrolysis whereas modification of the 3′-terminal sugar has a major effect. tRNA terminating with a 3′-phosphate is completely inactive [3]. This enzyme can convert a tRNA precursor into a mature tRNA [2]. |
| Cofactor | Mg2+?or?cobalt cation?or?Mn2+ |
| History | |
| Reactions | Exonucleolytic cleavage that removes extra residues from the 3′-terminus of tRNA to produce 5′-mononucleotides. |
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