S-adenosylmethionine:tRNA ribosyltransferase-isomerase EC#: 2.4.99.17; ChemWhat Code: 1377861

Product Name S-adenosylmethionine:tRNA ribosyltransferase-isomerase
Example Structure Example Structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase EC#: 2.4.99.17
Synonyms QueA, QueA enzyme, queuosine biosynthesis protein, queuosine biosynthesis protein QueA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase, TM0574
EC Number 2.4.99.17
CAS Registry Number
Comments The reaction is a combined transfer and isomerization of the ribose moiety of S-adenosyl-L-methionine to the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. It is part of the queuosine biosynthesis pathway.
Cofactor
History
Reactions S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.

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