The enzyme is present in the poppy, Papaver somniferum. At pH 8-9 the product, 7-O-acetylsalutaridinol, spontaneously closes the 4¡ú5 oxide bridge by allylic elimination to form the morphine precursor thebaine.
Cofactor
History
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Acetyl-CoA + salutaridinol = CoA + 7-O-acetylsalutaridinol.