sanguinarine reductase EC#: 1.3.1.107; ChemWhat Code: 1374085
| Product Name | sanguinarine reductase |
| Example Structure |  |
| Synonyms | SARED1 |
| EC Number | 1.3.1.107 |
| CAS Registry Number | |
| Comments | The enzyme, purified from the California poppy (Eschscholzia californica), is involved in detoxifying the phytoalexin sanguinarine produced by poppy itself (cf. EC 1.5.3.12, dihydrobenzophenanthridine oxidase), when it binds to the cell wall of the poppy cell. The reaction with NADPH is up to three times faster than that with NADH at low concentrations (<10 uM) of the dinucleotide. At higher concentrations the reaction with NADPH is inhibited but not that with NADH [1]. |
| Cofactor | |
| History | |
| Reactions | (1) Dihydrosanguinarine + NAD(P)(+) = sanguinarine + NAD(P)H. (2) Dihydrochelirubine + NAD(P)(+) = chelirubine + NAD(P)H. |
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