sarcosine reductase EC#: 1.21.4.3; ChemWhat Code: 1376090
| Product Name | sarcosine reductase |
| Example Structure |  |
| Synonyms | |
| EC Number | 1.21.4.3 |
| CAS Registry Number | |
| Comments | The reaction is observed only in the direction of sarcosine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for sarcosine binding and methylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.2 (glycine reductase) and EC 1.21.4.4 (betaine reductase). |
| Cofactor | |
| History | |
| Reactions | Acetyl phosphate + methylamine + thioredoxin disulfide + H(2)O = N-methylglycine + phosphate + thioredoxin. |
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