sedolisin EC#: 3.4.21.100; ChemWhat Code: 1380636
| Product Name | sedolisin |
| Example Structure |  |
| Synonyms | EC 3.4.23.37, grifolisin, PCP, Pepstatin-insensitive carboxyl proteinase, PSCP, pseudomonalisin, pseudomonapepsin, Pseudomonas serine-carboxyl proteinase, Pseudomonas sp. pepstatin-insensitive carboxyl proteinase, scytalidolisin, scytalidopepsin A, SedA, SedB, SedC, SedD, sedolisin |
| EC Number | 3.4.21.100 |
| CAS Registry Number | |
| Comments | An enzyme secreted by?Pseudomonas?sp. No. 101. Optimum pH is 4. It is distinguished from EC?3.4.21.101, xanthomonalisin, by its insensitivity to EPNP and from EC?3.4.23.31, scytalidopepsin B, by this property and by its unrelated amino-acid sequence. Inhibited by tyrostatin, a peptide aldehyde [2]. Type example of peptidase family?S53. |
| Cofactor | |
| History | |
| Reactions | Hydrolysis of the B chain of insulin at 13-Glu-|-Ala-14, 15-Leu-|-Tyr-16 and 25-Phe-|-Tyr-26 and angiotensin I at 4-Tyr-|-Ile-5. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe-|-Phe(NO(2))-Arg-Leu. |
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