sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming) EC#: 1.1.1.325; ChemWhat Code: 1373438
| Product Name | sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming) |
| Example Structure |  |
| Synonyms | MDSPR, sepiapterin reductase, SPR |
| EC Number | 1.1.1.325 |
| CAS Registry Number | |
| Comments | This enzyme, isolated from the bacterium Chlorobium tepidum, catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. cf. EC 1.1.1.153, sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming). |
| Cofactor | |
| History | |
| Reactions | (1) L-threo-7,8-dihydrobiopterin + NADP(+) = sepiapterin + Nadph. (2) L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8- tetrahydropterin + 2 Nadph |
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