single-stranded DNA cytosine deaminase EC#: 3.5.4.38; ChemWhat Code: 1381487
Product Name
single-stranded DNA cytosine deaminase
Example Structure
Synonyms
activation-induced cytidine deaminase, activation-induced deaminase, AICDA, AID
EC Number
3.5.4.38
CAS Registry Number
Comments
The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G) [2]. The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences.
Cofactor
History
Reactions
Cytosine in single-stranded Dna + H(2)O = uracil in single-stranded dna + NH(3).