single-stranded DNA cytosine deaminase EC#: 3.5.4.38; ChemWhat Code: 1381487

Product Name single-stranded DNA cytosine deaminase
Example Structure Example Structure of single-stranded DNA cytosine deaminase EC#: 3.5.4.38
Synonyms activation-induced cytidine deaminase, activation-induced deaminase, AICDA, AID
EC Number 3.5.4.38
CAS Registry Number
Comments The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G) [2]. The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences.
Cofactor
History
Reactions Cytosine in single-stranded Dna + H(2)O = uracil in single-stranded dna + NH(3).

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