| Product Name |
single-stranded DNA cytosine deaminase |
| Example Structure |
 |
| Synonyms |
activation-induced cytidine deaminase, activation-induced deaminase, AICDA, AID |
| EC Number |
3.5.4.38 |
| CAS Registry Number |
|
| Comments |
The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G) [2]. The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences. |
| Cofactor |
|
| History |
|
| Reactions |
Cytosine in single-stranded Dna + H(2)O = uracil in single-stranded dna + NH(3). |
