sirohydrochlorin ferrochelatase EC#: 4.99.1.4

Product Name sirohydrochlorin ferrochelatase
Example Structure Example Structure of sirohydrochlorin ferrochelatase EC#: 4.99.1.4
Synonyms CbiX, CysG, Met8p, More, SirB, sirohydrochlorin ferrochelatase, sirohydrochlorin-ferrochelatase
EC Number 4.99.1.4
CAS Registry Number
Comments This enzyme catalyses the third of three steps leading to the formation of siroheme from uroporphyrinogen III. The first step involves the donation of two?S-adenosyl-L-methionine-derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC?2.1.1.107, uroporphyrin-III C-methyltransferase) and the second step involves an NAD+-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC?1.3.1.76, precorrin-2 dehydrogenase). In?Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in?Bacillus megaterium, three separate enzymes carry out each of the steps, with SirB being responsible for the above reaction.
Cofactor
History
Reactions Siroheme + 2 H(+) = sirohydrochlorin + Fe(2+).

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