site-1 protease EC#: 3.4.21.112; ChemWhat Code: 1380658
| Product Name | site-1 protease |
| Example Structure |  |
| Synonyms | convertase site 1 protease, dS1P, hSKI-1, kexin, membrane-bound transcription factor protease, site-1, MEROPS S08.8063, PCSK8, prohormone convertase subtilisin-kexin isoenzyme-1, protease responsible for activating sigmaW, PrsW, S08.063, S1P, site 1 protease, site-1 protease, SK-1, SKI-1, SKI-1/S1P, SREBP site 1 protease, subtilisin kexin isoenzyme-1, subtilisin kexin isozyme 1/site 1 protease, subtilisin kexin isozyme-1, subtilisin kexin isozyme-1(SK-1)/site 1 protease (S1P), subtilisin kexin isozyme-1/site-1 protease, subtilisin kexin-isozyme-1, subtilisin-kexin isoenzyme-1, subtilisin-kexin-isozyme, subtilisin/kexin isozyme 1 |
| EC Number | 3.4.21.112 |
| CAS Registry Number | |
| Comments | Cleaves sterol regulatory element-binding proteins (SREBPs) and thereby initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholesterol and unsaturated fatty acids into the bloodstream [1]. The enzyme also processes pro-brain-derived neurotrophic factor and undergoes autocatalytic activation in the endoplasmic reticulum through sequential cleavages [5]. The enzyme can also process the unfolded protein response stress factor ATF6 at an Arg-His-Lys-Lys©à site [4,8], and the envelope glycoprotein of the highly infectious Lassa virus [5,8] and Crimean Congo hemorrhagic fever virus at Arg-Arg-Lys-Lys©à [7,8]. Belongs in peptidase family?S8A. |
| Cofactor | |
| History | |
| Reactions | Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3. |
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