Snake venom factor V activator EC#: 3.4.21.95; ChemWhat Code: 1380628

Product Name Snake venom factor V activator
Example Structure Example Structure of Snake venom factor V activator EC#: 3.4.21.95
Synonyms blood coagulation factor V-activating proteinase, Factor V activator, Factor V-activating enzyme, Factor V-activating proteinase alpha, Factor V-activating proteinase gamma, FV activating enzymes, Human blood coagulation Factor V activating enzymes, LVV-V, Russell’s viper venom factor V (FV) activator, RVV-V, RVV-Vgamma, Snake venom factor V activator alpha, Snake venom factor V activator gamma, VLFVA
EC Number 3.4.21.95
CAS Registry Number 123757-15-3;123757-16-4;123757-17-5;123757-18-6;471269-12-2
Comments Known from venom of?Vipera russelli. Inhibited by di-isopropyl fluorophosphate, unlike the metallopeptidase russellysin (EC?3.4.24.58) that is specific for factor X [1]. In peptidase family?S1?(trypsin family) [2].
Cofactor
History
Reactions Fully activates human clotting factor V by a single cleavage at the 1545- Trp-Tyr-Leu-Arg-|-Ser-Asn-Asn-Gly-1552 bond. Cattle, but not rabbit, factor V is cleaved, and no other proteins of the clotting system are attacked. Esterase activity is observed on Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on Phe-pipecolyl-Arg-NHPhNO(2).

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