Sotorasib CAS#: 2296729-00-3; ChemWhat Code: 1417439
Identification
| Product Name | Sotorasib |
| IUPAC Name | 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one |
| Molecular Structure |  |
| CAS Registry Number | 2296729-00-3 |
| MDL Number | MFCD32880274 |
| Synonyms | otorasib AMG-510 2296729-00-3 AMG510 Lumakras AMG-510 racemate 2252403-56-6 AMG 510 Kras G12C inhibitor 9 sotorasibum 4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one Kras mutant-targeting AMG 510 2B2VM6UC8G Sotorasib [INN] Sotorasib [USAN] UNII-2B2VM6UC8G CHEMBL4535757 CHEBI:178199 2296729-00-3 (racemate) |
| Molecular Formula | C30H30F2N6O3 |
| Molecular Weight | 560.6 |
| InChI | InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1 |
| InChI Key | NXQKSXLFSAEQCZ-SFHVURJKSA-N |
| Canonical SMILES | C[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C |
Physical Data
No data available
Spectra
No data available
Route of Synthesis (ROS)
No data available
Safety and Hazards
No data available
Other Data
| Use Pattern |
| Sotorasib CAS#: 2296729-00-3 is a selective covalent inhibitor of KRAS G12C for the treatment of patients with advanced KRAS G12C mutated non-small cell lung cancer (NSCLC) who have received prior systemic therapy. |
Buy Reagent | |
| No reagent supplier? | Send quick inquiry to ChemWhat |
| Want to be listed here as a reagent supplier? (Paid service) | Click here to contact ChemWhat |
Approved Manufacturers | |
| Want to be listed as an approved manufacturer (Requires approvement)? | Please download and fill out this form and send back to approved-manufacturers@chemwhat.com |
Contact Us for Other Help | |
| Contact us for other information or services | Click here to contact ChemWhat |