sphingolipid 4-desaturase EC#: 1.14.19.17; ChemWhat Code: 1375782

Product Name sphingolipid 4-desaturase
Example Structure Example Structure of sphingolipid 4-desaturase EC#: 1.14.19.17
Synonyms degenerative spermatocyte desaturase, DegS, Degs1, DEGS2, dehydroceramide desaturase, DELTA4 desaturase, DELTA4DES, DES-1, DES1, DES2, DHCD, dihydroceramide C4-desaturase, dihydroceramide DELTA4-(E)-desaturase, dihydroceramide DELTA4-desaturase, dihydroceramide DELTA4-desaturase 1, dihydroceramide desaturase, dihydroceramide desaturase 1, dihydroceramide desaturase 2, dihydroceramide desaturase-1, dihydroceramide-desaturase-1, drosophila degenerative spermatocyte 1, drosophila degenerative spermatocyte 2, ifc, LCB DELTA4 desaturase, MDES, membrane lipid desaturase, MLD, SPBC3B8.07c, sphingolipid DELTA4-desaturase
EC Number 1.14.19.17
CAS Registry Number
Comments The enzyme, which has been characterized from plants, fungi, and mammals, generates a trans double bond at position 4 of sphinganine bases in sphingolipids [1]. The preferred substrate is dihydroceramide, but the enzyme is also active with dihydroglucosylceramide [2]. Unlike EC 1.14.19.29, sphingolipid 8-desaturase, this enzyme does not contain an integral cytochrome b5 domain [4] and requires an external cytochrome b5 [3]. The product serves as an important signalling molecules in mammals and is required for spermatide differentiation [5].
Cofactor
History
Reactions A dihydroceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (4E)-sphing- 4-enine ceramide + 2 ferricytochrome b5 + 2 H(2)O.

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