sphingolipid 8-(E/Z)-desaturase EC#: 1.14.19.29; ChemWhat Code: 1375794
| Product Name | sphingolipid 8-(E/Z)-desaturase |
| Example Structure |  |
| Synonyms | 8 fatty acid desaturase, 8-sphingolipid desaturase, D8A, D8B, D8C, D8D, DELTA8 Des, Delta8 sphingolipid desaturase, DELTA8(E,Z)-sphingolipid desaturase, Delta8-fatty-acid desaturase 1, Delta8-fatty-acid desaturase 2, DELTA8-sphingolipid desaturase, Delta8-sphingolipid desaturase 1, Delta8-sphingolipid desaturase 2, Delta8-sphingolipid desaturase 3, DELTA8-sphingolipid-desaturase, DES8, DXDES, LCB DELTA8 desaturase, PtD8A, PtD8B, PtD8C, SLD, SLD1, SLD2, sphingoid long-chain base DELTA8 desaturase, sphingolipid DELTA8-desaturase |
| EC Number | 1.14.19.29 |
| CAS Registry Number | |
| Comments | The enzymes from higher plants convert sphinganine, 4E-sphing-4-enine and phytosphinganine into E/Z-mixtures of ¦¤8-desaturated products displaying different proportions of geometrical isomers depending on plant species. The nature of the actual desaturase substrate has not yet been studied experimentally. The enzymes contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase [1]. The homologous enzymes from some yeasts and diatoms, EC 1.14.19.18, sphingolipid 8-(E)-desaturase, act on sphing-4-enine ceramides and produce only the trans isomer. |
| Cofactor | |
| History | |
| Reactions | (1) A (4R)-4-hydroxysphinganine ceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (4R,8E)-4-hydroxysphing-8-enine ceramide + 2 ferricytochrome b5 + 2 H(2)O. (2) A (4R)-4-hydroxysphinganine ceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 ferricytochrome b5 + 2 H(2)O. |
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