sphingolipid C4-monooxygenase EC#: 1.14.18.5; ChemWhat Code: 1375753
| Product Name | sphingolipid C4-monooxygenase |
| Example Structure |  |
| Synonyms | bifunctional sphingolipid D4-desaturase/C4-hydroxylase, DES2, DHS hydroxylase, dihydroceramide hydrolase, dihydroceramide hydroxylase, LmjF_26_1670, SBH1, SBH2, SC4H, sphinganine C4-hydroxylase, sphinganine C4-monooxygenase, sphingolipid C4-hydroxylase, sphingolipid delta(4)-desaturase/C4-monooxygenase, sphingolipid hydroxylase, SUR2, Sur2p, SYR2, Syr2p |
| EC Number | 1.14.18.5 |
| CAS Registry Number | |
| Comments | The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase [4]. |
| Cofactor | |
| History | |
| Reactions | A dihydroceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (4R)-4- hydroxysphinganine ceramide + 2 ferricytochrome b5 + H(2)O. |
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