M50.002, S55.001, SpoIVB, SpoIVB serine peptidase, SpolVFB, sporulation protein SpolVFB, stage IV sporulation protein FB
EC Number
3.4.21.116
CAS Registry Number
Comments
This enzyme plays a central role in a regulatory checkpoint (the ¦ÒK?checkpoint), which coordinates gene expression during the later stages of spore formation in?Bacillus subtilis?[1,3]. The enzyme activates proteolytic processing of a sporulation-specific sigma factor, pro-¦ÒK, to its mature and active form, ¦ÒK, by self-cleavage [1,3]. The enzyme is also subject to secondary proteolysis, which presumably inactivates SpoIVB [3]. The enzyme is also essential for the formation of heat-resistant spores. Belongs in peptidase family?S55.
Cofactor
History
Reactions
Self-cleaves 52-Val-|-Asn-53, 62-Ala-|-Phe-63 and 74-Val-|-Thr-75 at the N-terminus of SpoIVB.
