squalene synthase EC#: 2.5.1.21; ChemWhat Code: 1377905
| Product Name | squalene synthase |
| Example Structure |  |
| Synonyms | BbSS, CrSQS, dt-ySQase, Erg9, EtSS, farnesyl-diphosphate farnesyltransferase, farnesyl-diphosphate:farnesyldiphosphate farnesyltransferase, farnesyldiphosphate farnesyltransferase 1, farnesyldiphosphate:farnesyldiphosphate farnesyltransferase, farnesyltransferase, FDFT1, hSQS, presqualene synthase, presqualene-diphosphate synthase, SQase, SQS, SQS1, squalene synthase, squalene synthase 1, squalene synthetase, SS1, SSase, SSN, synthase, squalene |
| EC Number | 2.5.1.21 |
| CAS Registry Number | 9077-14-9 |
| Comments | This microsomal enzyme catalyses the first committed step in the biosynthesis of sterols. The enzyme from yeast requires either Mg2+ or Mn2+ for activity. In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP) [8]. High concentrations of FPP inhibit the production of squalene but not of PSPP [8]. |
| Cofactor | Mn2+ or Mg2+ |
| History | |
| Reactions | 2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+). |
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