steroid 21-monooxygenase EC#: 1.14.14.16; ChemWhat Code: 1375517
| Product Name | steroid 21-monooxygenase |
| Example Structure |  |
| Synonyms | 17alpha-hydroxyprogesterone 21-hydrolase, 21-hydroxylase, 21-hydroxylase cytochrome P-450, 21OH, C3B21RA protein, CYP21, CYP21A2, CYP2D, Cytochrome P-450 specific for steroid C-21 hydroxylation, cytochrome P-450-linked mixed function oxidase system, cytochrome P-450C-21, cytochrome p450 21A2, cytochrome P450 steroid 21-hydroxylase, cytochrome P450c21, EC 1.14.1.8, EC 1.99.1.11, P-450(C21), P450 oxidoreductase-21-hydroxylase, P450-C21, P450-C21B, P450c21, Progesterone 21-hydroxylase, Steroid 21-hydroxylase, steroid 21-hydroxylase system, steroid 21-hydroxylation system, steroid cytochrome P450 21-hydroxylase |
| EC Number | 1.14.14.16 |
| CAS Registry Number | 9029-68-9 |
| Comments | A P-450 heme-thiolate protein responsible for the conversion of progesterone and 17¦Á-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol. The electron donor is EC 1.6.2.4, NADPH¡ªhemoprotein reductase. |
| Cofactor | heme-thiolate |
| History | |
| Reactions | A C(21) steroid + [reduced NADPH–hemoprotein reductase] + O(2) = a 21-hydroxy-C(21)-steroid + [oxidized NADPH–hemoprotein reductase] + H(2)O. |
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