sterol 22-desaturase EC#: 1.14.19.41; ChemWhat Code: 1375806
| Product Name | sterol 22-desaturase |
| Example Structure |  |
| Synonyms | C-22 sterol desaturase, CTP61, CYP61, CYP710A, CYP710A1, CYP710A11, CYP710A13, CYP710A14, CYP710A2, CYP710A4, cytochrome P-450 sterol DELTA22-desaturase, cytochrome P-45061, cytochrome P45061, DELTA22-desaturase, ERG5, Erg5p, P450 61, Sd1, sterol 22-desaturase, sterol C-22 desaturase, sterol C22 desaturase, sterol C22-desaturase, sterol DELTA22-desaturase |
| EC Number | 1.14.19.41 |
| CAS Registry Number | |
| Comments | A heme-thiolate protein (P450). The enzyme, found in yeast and plants, catalyses the introduction of a double bond between the C-22 and C-23 carbons of certain sterols. In yeast the enzyme acts on ergosta-5,7,24(28)-trien-3¦Â-ol, a step in the biosynthesis of ergosterol. The enzyme from the plant Arabidopsis thaliana acts on sitosterol and 24-epi-campesterol, producing stigmasterol and brassicasterol, respectively. |
| Cofactor | heme-thiolate |
| History | |
| Reactions | Ergosta-5,7,24(28)-trien-3-beta-ol + Nadph + O(2) = ergosta- 5,7,22,24(28)-tetraen-3-beta-ol + NADP(+) + 2 H(2)O. |
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